SVDis seen on MRI studies and often disregarded.
The MRI will indicate white matter lacunar infarct or white matter hyperintensities that are read as signs of normal aging. A recent study suggests linkage between SVD and AD and the consensus is that if anything, the presence of SVD will tend to augment and increase the effects of Alzheimer’s dementia. A new study supports the theory that the physiological pathways of Cerebral Small Vessel disease and Alzheimer’s disease are interconnected. Cerebral small vessel disease can provoke amyloid pathology and Alzheimer’s associated cerebral amyloid pathology can lead to auxiliary vascular damage. An association was found between amyloid pathology and vascular damage. The idea being that small vessel disease and the vascular risk factor increases the risk of developing Alzheimer’s and patients who are APOE-e4 carriers resulted in an even stronger association. The study suggests that different forms of small vessel disease and Alzheimer’s dementia can coexist and make cognition worse. Neurology Today June 19, 2014; Kester, MI, Goos, JDC,