Neurology Today (1-6-2011) cited study finding that children with typical autism are more likely to have impaired mitochondrial function; it remains unknown whether this is cause or effect. What is known is that mitochondrial dysfunction can amplify and make brain function worse. Further that the highest levels of abnormalities were found in the brain tissue with the highest energy demands. Children in the study were 2 to 5 years of age with severe language and behavior deficits and compared to controls. One explanation is the presence of higher oxidative stress and/or inadequate removal of harmful toxins in the autism population. Mitochondrial problems can create less capacity for cells to produce ATP, the energy needed for working cells; they are also sensitive to stress suggesting that the problem may worsen when taxed by environmental factors of infection and inflammation.